Tobias D. Journal of the American Chemical Society , 12 , Vyas, Bhavesh Variya, Manjunath D. We found that added halide, necessary in some cross-coupling chemistry of aryl sulfonates, was an unnecessary additive and even inhibited the amination chemistry.
Organic Letters , 15 7 , Mark D.
The aim of this communication is to point out the excellent in vitro and in vivo behavior of the aryltriflate group, thus encouraging future efforts aiming to incorporate this moiety in future clinical candidates with appropriate druglike properties. Priyadarshini, P. RSC Advances , 3,
The Journal of Organic Chemistry , 70 21 , Harrington,, William F. A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB cells through topoisomerase inhibition. Chemistry and Physics of Lipids , , Journal of the American Chemical Society , 11 ,
The Journal of Organic Chemistry , 82 24 , Harrington,, William F.
Although triflates are broadly used in organic synthesis, this group is scarcely used in medicinal chemistry programs. Journal of Medicinal Chemistry ,
Organometallics , 33 20 , Soprano, D. Synthesis and preliminary evaluation of affinity to retinoic acid receptors for new organosilicon-based retinoids.
James T. Irina P.
Dejan D. The Journal of Organic Chemistry , 70 6 ,
Stevens,, Natalie M. Cited By This article is cited by publications. The Journal of Organic Chemistry , 70 6 , Stephens, John C.
Russian Chemical Bulletin , 65 11 , Organic Letters , 15 7 , European Journal of Medicinal Chemistry , 81, Chiral catalysts for the asymmetric cycloaddition of carbon dioxide with epoxides. Chemistry - A European Journal , 13 Bidlack and John L.
Although triflates are broadly used in organic synthesis, this group is scarcely used in medicinal chemistry programs. We assume that presumption of the biological liability of this moiety discouraged medicinal chemists from further investigation due to the possible in vivo formation of potentially toxic phenol derivatives and trifluoromethanesulfonic acid; thus, metabolic stability was carefully examined. Harrington,, William F.