Gharby, H. Harhar, Z. Bouzoubaa, A. Asdadi, A. El Yadini, Z. Chemical characterization and oxidative stability of seeds and oil of sesame grown in Morocco.
Journal of the Saudi Society of Agricultural Sciences , 16 2 , Bahabadi, Eiichiro Ono, Jun Murata. Lignan Biosynthesis for Food Bioengineering.
Effects of phytase supplementation on growth performance, jejunum morphology, liver health, and serum metabolites of Japanese quails fed sesame Sesamum indicum meal-based diets containing graded levels of protein. Tropical Animal Health and Production , 48 6 , Sesame fractions and lipid profiles: a systematic review and meta-analysis of controlled trials.
British Journal of Nutrition , , The Journal of Korean Oriental Pediatrics , 29, Vasundhra Shukla, Prameela Kandra. Development, physico-chemical and sensory evaluation of natural nutra candy. Journal of Food Science and Technology , 52, Pathak, A. Bhaduri, K. Bhat, A. Tracking sesamin synthase gene expression through seed maturity in wild and cultivated sesame species - a domestication footprint. Plant Biology , 17 Essences in Metabolic Engineering of Lignan Biosynthesis.
Metabolites , 5 2 , Journal of Oleo Science , 64, Analytical Letters , 47 7 , Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture. Glycoconjugate Journal , 31 3 , Antioxidative effects of fermented sesame sauce against hydrogen peroxide-induced oxidative damage in LLC-PK1 porcine renal tubule cells.
Nutrition Research and Practice , 8 2 , Mohamed, M. Effect of sesame seeds or oil supplementation to the feed on some physiological parameters in Japanese Quail. The Scientific World Journal , , Rats were fed either a lignan-free diet, a diet containing 0.
Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involved in hepatic fatty acid oxidation. The increase was much greater with sesamolin than with sesamin.
These lignans increased parameters of hepatic fatty acid oxidation in an additive manner when added simultaneously to an experimental diet. Terpenoid biosynthesis. The enzyme 1-deoxy-D-xylulosephosphate synthase catalyzes the first step of the MEP pathway and its three distinct isoforms are well-characterized Matsushima et al.
ESTs of most genes in the MEP pathway, but never the MVA pathway, are already obtained by transcriptome analysis although those are not completely cloned and characterized yet Ioki et al. Squalene synthase, which is widely observed in eukaryotes, catalyzes two step reactions: namely, 1 condensation of two farnesyldiphosphates FPP, triterpene to form PSPP and 2 dephospholylation, cyclopropane cleavage, carbon bond reformation and NADPH-dependent reduction of PSPP to produce squalene Okada, ; Jennings et al.
These two reactions are catalyzed at the domain 3 and 4 for 1st reaction and the domain 5 for 2nd reaction of six domains sequentially Gu et al.
Botoryococcus squalene synthase BSS was isolated by methods of homology screening of cDNA library based on its putative homologous sequence obtained by the degenerate PCR method to already known squalene synthase Okada et al. BSS expressed in E. Squalene synthase like-1 SSL-1 is a protein which is homologous to BSS possessing quite different amino acid sequence at the domain 5 Niehaus et al. The purified SSL-1 did not function to produce neither botryococcene nor squalene in vitro.
Instead, SSL-1 stimulates botryococcene production when it was added to B. These results suggested that SSL-1 functions as PSPP synthase but subsequent reactions for squalene synthesis are catalyzed by other enzymes Niehaus et al. These results suggest that the pathway for terpenoid hydrocarbon biosynthesis in B.
After the synthesis, both squalene and botryococcene are subsequently methylated but the number of methylation is variable. The name of botryococcene was originally designated to methylated botryococcene but now it is used for both compounds. The methyl group is transferred from S-adenosyl methionine by triterpene methyltransferases TMTs although completely methylated tetra-methylated squalene and botryococcene is not yet produced in vitro Niehaus et al.
Carbon flow and energy balance in lipid and hydrocarbon biosynthetic pathways In Table 3 and Fig. GAP should be the primary metabolite during photosynthesis and transported into the cytosol. GAP production mostly depends on carbon fixation rate by the photosynthetic C3 cycle and the process seems to be the most effective limiting factor for hydrocarbon production. Gene expression level for fatty acid synthesis is relatively higher in race A fatty hydrocarbon than race B terpenoid hydrocarbon in B.
Transcriptional regulation network of fatty acid metabolism is well studied in E. Carbon allocation into lipids is known to be affected by environmental change via metabolic regulation; e. On the other hand, such environmental changes do not affect carbon allocation into hydrocarbon in B. Supply of inorganic and organic carbon sources, nutrient deficiency and low-temperature are empirically known to be stimulating factors for lipid biosynthesis.
Enrichment of CO2 as inorganic carbon source stimulated lipid biosynthesis and cell growth by accelerating photosynthetic carbon fixation in microalgae Kumar et al.
Bioscience, Biotechnology, and Biochemistry , 74 8 ,
Martin Lo. Preventive effect of sesame seed cake on hyperglycemia and obesity against high fructose-diet induced Type 2 diabetes in rats.
ESTs of most genes in the MEP pathway, but never the MVA pathway, are already obtained by transcriptome analysis although those are not completely cloned and characterized yet Ioki et al. Bacterial gene for the aldehyde-forming fatty acyl-CoA reductase was identified, but not eukaryotic gene yet. Essences in Metabolic Engineering of Lignan Biosynthesis. Development, physico-chemical and sensory evaluation of natural nutra candy. So, acyl-CoA can react with an alpha-carbon of fatty acid instead of carbonyl unit of the aldehyde Sukovich et al.
PCC is surrounded by cell wall involving unique glycolipids as a component heterocyst glycolipid: HGL Bauersachs et al. Bioscience, Biotechnology, and Biochemistry , 74 8 , Effect of sesame seeds or oil supplementation to the feed on some physiological parameters in Japanese Quail. The race B hydrocarbons are methylsqualene and botryococcene which are specifically produced by B. Supply of inorganic and organic carbon sources, nutrient deficiency and low-temperature are empirically known to be stimulating factors for lipid biosynthesis. Sesame seeds rich in lignans from two lines, and , lines established in this laborary, and those from a conventional cultivar Masekin were employed.
Properties of the race B hydrocarbons are mostly well-known although the race L is still enigmatic. Sesamin and sesamolin were equally effective in lowering parameters of lipogenesis. Bridle, Chris G.